It's Time for Summer: An Analysis of Recent Policy and Funding Opportunities

Recommends ways to improve and expand summer learning programs by better coordinating federal, state and local programs, including ensuring that federal program regulations explicitly allow spending for summer programs and creating funding collaboratives

Osprey Summer: Ospreys Nesting on Flaming Gorge

The osprey, sometimes known as the fish hawk is one of Utah\u27s rare and unique raptors. The osprey\u27s diet is almost exclusively fish. Considering the osprey has evolved both physically and behaviorally to catch fish, their distribution is quite limited in a state as dry as Utah. Most ospreys only pass through Utah on their northern or southern migration but a few stop, build nests, hatch and raise their young

AP-1cFos/JunB/miR-200a regulate the pro-regenerative glial cell response during axolotl spinal cord regeneration

© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Sabin, Keith Z., Jiang, Peng, Gearhart, Micah D., Stewart, Ron, & Echeverri, Karen. AP-1cFos/JunB/miR-200a regulate the pro-regenerative glial cell response during axolotl spinal cord regeneration. Communications Biology, 2(91), (2019), doi:10.1038/s42003-019-0335-4.Salamanders have the remarkable ability to functionally regenerate after spinal cord transection. In response to injury, GFAP+ glial cells in the axolotl spinal cord proliferate and migrate to replace the missing neural tube and create a permissive environment for axon regeneration. Molecular pathways that regulate the pro-regenerative axolotl glial cell response are poorly understood. Here we show axolotl glial cells up-regulate AP-1cFos/JunB after injury, which promotes a pro-regenerative glial cell response. Injury induced upregulation of miR-200a in glial cells supresses c-Jun expression in these cells. Inhibition of miR-200a during regeneration causes defects in axonal regrowth and transcriptomic analysis revealed that miR-200a inhibition leads to differential regulation of genes involved with reactive gliosis, the glial scar, extracellular matrix remodeling and axon guidance. This work identifies a unique role for miR-200a in inhibiting reactive gliosis in axolotl glial cells during spinal cord regeneration.This reseach was supported by a Regenerative Medicine Minnesota Grant and a NIH NCID R01 to KE. KZS has been supported by a NIH T32 GM113846 grant

Development of an Advanced Net‐Centric Communication Management Suite: Multi‐Modal Communication

Even with advanced collaborative technology, communication remains a critical component to the success of a mission. Command and Control (C2) operators rely heavily on radio and chat communication to efficiently plan, direct, coordinate, and control assets. With the shift towards network‐centric warfare, standard radio communication needs to meet the needs of today’s warfighter. A net‐centric communication management suite called Multi‐Modal Communication (MMC) has been developed to increase the performance and situational awareness of the operator while also alleviating the workload and errors associated with this communication intensive environment. This integrated system captures, displays, records, and archives radio and chat‐based communication to better equip the warfighters by providing instant access to past transmission as well as increasing the intelligibility of current messages. This poster and demonstration explores the development and testing of these advanced tools as compared to standard radio and chat interfaces. This study examined the performance associated with monitoring multiple communication channels with access to different tools. Performance was analyzed in regards to message detection, response accuracy and time. Data showed that MMC provides a balance between the speed of radio listening and the accuracy and datacapturing capabilities of chat displays. MMC can be a beneficial tool to C2 operators in its ability to increase intelligibly while providing a persistent, searchable visual display of voice and chat communication

Regulation of signal transducers and activators of transcription (STATs) by effectors of adipogenesis: Coordinate regulation of STATs 1, 5A, and 5B with peroxisome proliferator-activated receptor-γ and C/AAAT enhancer binding protein-α

We have recently demonstrated that three signal transducers and activators of transcription (STAT) family members are induced during adipocyte differentiation (Stephens et al., J. Biol. Chem. 271 (1996) 10441- 10444). Since STATs 1, 5A, and 5B are induced during adipocyte differentiation, we have examined the ability of these proteins to be regulated by components of the differentiation cocktail. In addition, we have examined the effects of potent effectors of differentiation on STAT protein expression during adipogenesis. A negative effector, tumor necrosis factor-α (TNFα), and a positive effector, a thiazolidinedione, were used in these experiments. Our results demonstrate that the expression of STATs 1, 5A, and 5B is not dramatically influenced by individual components of the differentiation cocktail. However, the expression of these three STAT family members tightly correlates with lipid accumulation. Moreover, the expression of STATs 1, 5A, and 5B, but not STATs 3 and 6, are regulated in an identical fashion to both C/AAAT enhancer binding proteins α and peroxisome proliferator-activated receptor-γ by TNFα and a thiazolidinedione. Furthermore, the expression of adipocyte-expressed JAK kinases are unaffected by effectors of differentiation. These findings suggest that three STAT family members may play a role in the regulation of adipocyte gene expression